Fractional lasers for the eye area worked better after 45
Short answer
In this randomised split-face trial, 18 Asian patients had three 1550 nm and 1565 nm non-ablative fractional laser treatments around the eyes. People aged 45 and over improved significantly; people under 45 did not. The two wavelengths performed the same, and side effects were limited and short-lived.
- Study
- Jia X, Zheng H, Huang L, et al. Aesthetic Plast Surg. 2025;49(15):4105-4121.
- Design
- Randomised split-face trial
- People
- 18
- Topic
- Periorbital photoaging
Why it matters
It suggests that who you are matters as much as which device you use: visible improvement depended on age.
What they did
- Split 18 patients into under-45 and 45-and-over groups.
- Treated each eye area with either a 1550 nm or 1565 nm non-ablative fractional laser, three times, six weeks apart.
- Measured wrinkle depth and volume, satisfaction, pain and side effects.
What they found
- Significant improvement in the 45-and-over group; no significant improvement under 45.
- No difference between the two wavelengths.
- Complications were limited and transient.
What it cannot tell you
- Small sample of 18.
- Clinic lasers, not home devices.
- Asian participants only, which limits generalisation.
Takeaway
Fractional lasers may show more visible change on skin with more established ageing. Younger users may see less.
Matching devices
Devices whose published technology match this study: MimiSilk Iris and Tria FRX. None of them was the device tested unless the study names it.
Not medical advice. Summary based on the published abstract; read the full paper for detail.